Utilizing liver-specific microRNA-122 to modulate replication of dengue virus replicon.

Abstract

microRNAs (miRNAs) are endogenous non-coding RNAs that spatiotemporally modulate mRNAs in a post-transcriptional manner. The engineering of viruses by insertion of a tissue-specific miRNA recognition element (MRE) into viral mRNA can restrict viral tissue tropism. In this study we employed dengue virus (DEN) replicons to investigate whether miRNAs are able… (More)
DOI: 10.1016/j.bbrc.2010.04.080

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