Utilizing RNA-Seq data for de novo coexpression network inference

  title={Utilizing RNA-Seq data for de novo coexpression network inference},
  author={Ovidiu D. Iancu and Sunita Kawane and Daniel Bottomly and Robert P. Searles and Robert Hitzemann and Shannon K. McWeeney},
  volume={28 12},
MOTIVATION RNA-Seq experiments have shown great potential for transcriptome profiling. While sequencing increases the level of biological detail, integrative data analysis is also important. One avenue is the construction of coexpression networks. Because the capacity of RNA-Seq data for network construction has not been previously evaluated, we constructed a coexpression network using striatal samples, derived its network properties and compared it with microarray-based networks. RESULTS The… CONTINUE READING
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