Utilizing Natural and Engineered Peroxiredoxins As Intracellular Peroxide Reporters


It is increasingly apparent that nature evolved peroxiredoxins not only as H2O2 scavengers but also as highly sensitive H2O2 sensors and signal transducers. Here we ask whether the H2O2 sensing role of Prx can be exploited to develop probes that allow to monitor intracellular H2O2 levels with unprecedented sensitivity. Indeed, simple gel shift assays… (More)
DOI: 10.14348/molcells.2016.2328

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