Utilization of zonisamide inpatients with chronic pain orepilepsy refractory to othertreatments: a retrospective,open label, uncontrolled studyin a VA hospital

@article{Hasegawa2004UtilizationOZ,
  title={Utilization of zonisamide inpatients with chronic pain orepilepsy refractory to othertreatments: a retrospective,open label, uncontrolled studyin a VA hospital},
  author={Hisanori Hasegawa},
  journal={Current Medical Research and Opinion},
  year={2004},
  volume={20},
  pages={577 - 580}
}
  • H. Hasegawa
  • Published 5 March 2004
  • Medicine
  • Current Medical Research and Opinion
SUMMARY Objectives: Zonisamide (1,2-benzisoxazole-3-methanesulfonamide) is a novel antiseizure medication approved for use in the United States as adjunct therapy in the treatment of partial seizures in adults with epilepsy. It has also been used to treat other conditions including intractable pain. The aim of this study was to determine the usefulness of zonisamide in patients whose seizures were not controlled after having been treated with at least three other currently available… 
Zonisamide for neuropathic pain in adults.
TLDR
A lack of evidence suggesting that zonisamide provides pain relief in any neuropathic pain condition is found, and effective medicines with much greater supportive evidence are available.
CLINICAL REVIEW: Use of antiepileptic drugs in the treatment of chronic painful diabetic neuropathy.
  • Aaron Vinik
  • Medicine, Psychology
    The Journal of clinical endocrinology and metabolism
  • 2005
TLDR
The evidence supporting the use of a new generation of antiepileptic drugs in painful diabetic neuropathy is reviewed and it is suggested that there is no single effective treatment.
Zonisamide as a Treatment for Partial Epileptic Seizures: A Systematic Review
TLDR
The authors present the results of a systematic literature review summarizing the current evidence on the efficacy and tolerability of zonisamide for the treatment of partial seizures, and of particular interest within this updated review are the recent data on the use ofZonisamide as monotherapy, as they might open new therapeutic avenues.
7 Antiepileptic drugs
Weight-reducing side effects of the antiepileptic agents topiramate and zonisamide.
TLDR
This chapter provides a review of potential mechanisms of actions of the two AEDs causing strong weight loss: topiramate and zonisamide based on in vivo studies in animal models for obesity and of clinical studies exploring these two drugs as single entities or in combinations with other agents.
Management of Peripheral Neuropathic Pain
  • B. Stacey
  • Medicine, Psychology
    American journal of physical medicine & rehabilitation
  • 2005
TLDR
An overview of the cellular mechanisms associated with neuropathic pain is presented, the results of randomized, controlled trials with the major classes of available drugs are summarized, and treatment options that provide a rational basis for pharmacotherapy are discussed.
Neuropathic agents and pain. New strategies.
  • M. Chong, B. Brandner
  • Medicine
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  • 2006
In silico docking studies and synthesis of new phosphoramidate derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole as potential antimicrobial agents
TLDR
It is suggested that the synthesized phosphoramidate derivatives of 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole will stand as the promising antimicrobial drug candidates in future.
Benzisoxazole: a privileged scaffold for medicinal chemistry.
TLDR
This review examines the state of the art in medicinal chemistry as it relates to the comprehensive and general summary of the different benzisoxazole analogs, their use as starting building blocks of multifarious architectures on scales sufficient to drive human drug trials.
...
...

References

SHOWING 1-10 OF 16 REFERENCES
Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures
TLDR
Zonisamide is effective and well tolerated as an adjunctive agent for refractory partial-onset seizures and the minimal effective dosage was 100mg/d, but 400 mg/d was the most effective dosage.
Zonisamide: Pharmacology and Clinical Efficacy in Epilepsy.
TLDR
This review will focus mainly on the pharmacodynamic properties of ZNS and its clinical efficacy in epilepsy.
Adverse Reactions to New Anticonvulsant Drugs
TLDR
The relatively late establishment of aplastic anaemia and hepatic failure as potentially fatal ADRs of felbamate, and of visual field constriction with vigabatrin, should serve as ample reminders that ADRs can appear at any time.
Current estimates from the National Health Interview Survey, 1996.
TLDR
During 1982-96, the prevalence of asthma increased and the rate and duration of hospitalizations decreased, as well as prevalence of chronic conditions and respondent assessed health status.
Current estimates from the National Health Interview Survey, 1994.
  • P. F. Adams, M. Marano
  • Medicine
    Vital and health statistics. Series 10, Data from the National Health Survey
  • 1995
This report on the 1988 civilian noninstitutionalized population residing in the US presents estimates of acute conditions episodes of persons injured restriction in activity limitation of activity
Current estimates from the National Health Interview Survey.
  • D. A. Dawson, P. F. Adams
  • Medicine, Sociology
    Vital and health statistics. Series 10, Data from the National Health Survey
  • 1987
TLDR
A selection of photos from the 2016/17 USGS report on quantitative hazard assessments of earthquake-triggered landsliding and liquefaction in the Czech Republic.
Zonisamide 922 Trial Group. Randomized controlled trial of zonisamide for the treatment of refractory partial-onset seizures
  • Neurology
  • 2001
Phase II clinical trial of a new antiepileptic drug, zonisamide (ZNA) in pediatric epilepsy patients
  • Shonika-Rinsho
  • 1987
...
...