The method of DDD (defined daily dose) was used to determine the drug utilization of NSAIDs and H2-blockers in two randomly chosen hospitals in Sofia during the last year period. The data were collected from hospital records. Seasonal variations in DDDs were compared for two groups of drugs. The utilization of diclofenac in the university hospital was higher than that in the city hospital. The utilization of indomethacin in the city hospital was higher in summer than in winter. The derivatives of propionic and acetic acids, piroxicam and sulindac, were mostly utilized in the university hospital. The overall ranitidine utilization and its autumn consumption in the city hospital were considerably higher in comparison with the university hospital.