Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione.

@article{Thompson1974UtilizationOO,
  title={Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione.},
  author={Emily A Thompson and Pentii K. Siiteri},
  journal={The Journal of biological chemistry},
  year={1974},
  volume={249 17},
  pages={5364-72}
}
The addition of androstenedione and NADPH to human placental microsomes results in a marked increase in the rate of 0 2 and NADPH utilization concomitant with estrogen formation. Initially, 5 to 12 moles of O2 and an equivalent amount of NADPH are consumed per mole of estrogen formed, the ratio varying from one microsomal preparation to another. In the… CONTINUE READING