Utilization of iron (III)-doped nanoshells for in vivo marking of nonpalpable tumors using a VX2 rabbit model.

Abstract

BACKGROUND We aimed to evaluate the potential for ultrasound (US) visible biodegradable nanoshells (NS) as an alternative to wire-guided localization for nonpalpable tumors in vivo. METHODS VX2 tumor was injected in bilateral thighs of 22 New Zealand rabbits and after 5 to 10 days, 1 tumor was marked with a wire as a control and the contralateral tumor was injected with 1 mL of 500 nm gas-filled silica NS under Doppler US. Tumors were excised after 24 hours. Chi-square was used for significance, P = .05. RESULTS One rabbit was excluded on postoperative day 1 due to equipment failure, no ill effects were observed from the NS. The NS were used to localize and resect 100% of marked tissue, 4/21 wires were displaced (P < .05). CONCLUSIONS We have shown that preoperatively injected US visible silica NS can be successfully used to mark nonpalpable tumors in vivo more consistently than WL.

DOI: 10.1016/j.amjsurg.2016.09.013

Cite this paper

@article{Ward2016UtilizationOI, title={Utilization of iron (III)-doped nanoshells for in vivo marking of nonpalpable tumors using a VX2 rabbit model.}, author={Erin P. Ward and James Wang and Natalie Mendez and Jian Yang and Chris Barback and Jessica Wang-Rodriguez and William C Trogler and Andrew C Kummel and Sarah Lynn Blair}, journal={American journal of surgery}, year={2016}, volume={212 6}, pages={1140-1146} }