Utilization of human liver microsomes to explain individual differences in paclitaxel metabolism by CYP2C8 and CYP3A4.

@article{Taniguchi2005UtilizationOH,
  title={Utilization of human liver microsomes to explain individual differences in paclitaxel metabolism by CYP2C8 and CYP3A4.},
  author={Ryoko Taniguchi and Toshio Kumai and Naoki Matsumoto and Minoru Watanabe and Koji Kamio and Satoshi Suzuki and Shinichi Kobayashi},
  journal={Journal of pharmacological sciences},
  year={2005},
  volume={97 1},
  pages={83-90}
}
Paclitaxel is widely used for treatment of malignant tumors. Paclitaxel is metabolized by CYP2C8 and CYP3A4, and these enzymes are known to differ between individuals, although the details have not been clarified. Recent progress in pharmacogenetics has shown that genetic polymorphisms of metabolic enzymes are related to these individual differences. We investigated the effect of the polymorphisms on paclitaxel metabolism by analyzing metabolic activities of CYP2C8 and CYP3A4 and expressions of… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Similar Papers

Loading similar papers…