Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen

Abstract

Tumor infiltrating lymphocytes (TILs) derived from tumor-bearing patients recognize tumor-associated antigens presented by major histocompatibility complex (MHC) class I molecules. The infusion of TIL586 along with interleukin (IL) 2 into an autologous patient with metastatic melanoma resulted in the objective regression of tumor. A gene encoding a tumor… (More)

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Cite this paper

@article{Wang1996UtilizationOA, title={Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen}, author={Ru Feng Wang and Maria R. Parkhurst and Yasuo Kawakami and Paul F. Robbins and Steven Rosenberg}, journal={The Journal of Experimental Medicine}, year={1996}, volume={183}, pages={1131 - 1140} }