Corpus ID: 2270556

Utility of serum protein-bound neutral hexoses and L-fucose for estimation of malignant tumor extension and evaluation of efficacy of therapy.

@article{Evans1974UtilityOS,
  title={Utility of serum protein-bound neutral hexoses and L-fucose for estimation of malignant tumor extension and evaluation of efficacy of therapy.},
  author={A S Evans and Melissa Dolan and Philip Z. Sobocinski and Fred A. Quinn},
  journal={Cancer research},
  year={1974},
  volume={34 3},
  pages={
          538-42
        }
}
Summary The method used permits correction for the influence of the neutral hexoses, galactose and mannose, on the apparent concentration of protein-bound l-fucose, as estimated by the Dische-Shettles CyR3 reaction. The values thus obtained, together with the serum concentrations of neutral hexoses, were evaluated in a series of patients, 109 of whom had confirmed diagnoses of cancer. In patients sampled prior to definitive treatment, 89.2% (74 of 83) had elevated ratios of fucose to protein… Expand
Serum protein‐bound carbohydrates and small cell carcinoma of the lung correlations with extent of disease, tumor burden, survival, and clinical response categories
TLDR
The biomarker index was found to be directly correlated with extent of primary disease, number of metastic sites, tumor burden, and clinical response categories assessed at serial time points. Expand
Fucosylated forms of alpha-1-antitrypsin that predict unresponsiveness to chemotherapy in ovarian cancer.
TLDR
Modified fucosylation of alpha 1-antitrypsin (F-AT) in the sera of ovarian cancer patients found to be particularly associated with the presence of liver metastases and frequently predated any clinical signs of a recurrence. Expand
Serum Glycoconjugates in Patients with Anemia and Myeloid Leukemia
TLDR
The present study suggests that the glycoconjugates investigated might be useful biochemical markers for differentiating anemic from leukemic conditions. Expand
Individual and combined usefulness of lipid associated sialic acid, mucoid proteins and hexoses as tumor markers in breast carcinoma.
TLDR
The present study suggests that the combination of the markers investigated might be useful for diagnosis and classification of breast carcinoma. Expand
Correlations among serum protein‐bound carbohydrates, serum glycoproteins, lymphocyte reactivity, and tumor burden in cancer patients
TLDR
The results suggest that serum protein‐bound carbohydrates or glycoproteins may be of adjunctive value in assessing tumor burden and immune reactivity in cancer patients. Expand
Tumor Markers in Leukemia: Evaluation of Serum Levels of Different Forms of Sialic Acid, Regan Isoenzyme and Lactate Dehydrogenase
TLDR
The study suggested that the biomarkers investigated might be used for differentiating anemic from leukemic conditions, however, more in-depth studies are indicated to assess their utility in classifying various leukemias. Expand
D-Mannose in human serum, measured as its aldononitrile acetate derivative.
TLDR
The sensitivity was such that 10 mg/L could be detected in a 0.1-mL sample of serum, and this method may be of use in diagnosing invasive Candida infection. Expand
Biologic markers in breast carcinoma. IV. Serum fucose‐protein ratio. Comparisons with carcinoembryonic antigen and human chorionic gonadotrophin
TLDR
Preliminary data indicate both serum fucose‐protein ratio and CEA frequently become elevated when patients progress from a disease free interval after surgery to recurrence. Expand
Quantitative gas-liquid chromatography of neutral sugars in human serum glycoproteins. Fucose, mannose, and galactose as predictors in ovarian and small cell lung carcinoma.
TLDR
Significantly elevated ratios of fucose, galactose, and mannose to serum protein were observed for patients with small cell lung and ovarian carcinomas and GLC--mass spectrometry confirmed the homogeneity of the chromatographic peaks for the neutral sugars of normal human serum glycoproteins. Expand
Correlation of serum levo - fucose levels among patients with oral squamous cell carcinoma, oral potentially malignant disorders and healthy controls
BACK GROUND: Oral cancer (OC) is one of the major health hazards in India, and approximately 80,000 new cases are diagnosed annually, mainly attributed to different forms of tobacco consumption.Expand
...
1
2
3
...

References

SHOWING 1-10 OF 19 REFERENCES
Partial Characterization of Carbohydrate Residues of Serum Glycoproteins in Neoplastic Disease
Abstract : The objective of this investigation was primarily to establish that the apparent increase in serum fucose levels in patients with malignant tumors is real and to obtain data as to itsExpand
Plasma Glycoproteins in Various Disease States Including Carcinoma
TLDR
Serial determinations of the plasma protein-bound galactose-mannose of the neutral glycoprotein fraction during treatment would suggest that the changes observed in these carbohydrates are intimately related to the neoplastic process. Expand
Serum fucose in the diagnosis of breast cancer
TLDR
In a total of 300 patients admitted to the hospital with undiagnosed breast masses, there was a definite relationship between higher concentrations of protein‐bound fucose and the presence of breast cancer. Expand
Serum protein-bound fucose levels in certain chronic diseases. A clinical-statistical study.
TLDR
The data obtained help support the view that the polysaccharide content of various serum glycoproteins found in increased quantities in disease is of varying composition, and that fucose is a mobile component of such proteins of particular physiological and pathological significance. Expand
Determination of L-Fucose in Glycoproteins. I. Effect of Nonfucose Moieties of Serum Glycoproteins
Abstract : The effect of galactose, mannose, and tryptophan on the determination of the methylpentose L-fucose in glycoproteins by the cysteine-sulfuric acid reaction is described. Under certainExpand
Serum Protein‐Bound Fucose in Patients with Gynecologic Cancers
TLDR
Serum protein-bound fucose levels were not influenced by precedent therapy and correlated well with the clinical stage of squamous-cell carcinoma of the cervix, which was found to be exceedingly helpful in establishing the presence of and in evaluating the extent of recurrent cervical cancer. Expand
The serum polysaccharide level in malignancy and in other pathological conditions.
TLDR
It is made that elevations of serum polysaccharide are involved in some way with tissue proliferation in patients with cancer and pathologic conditions studied. Expand
SERUM GLYCOPROTEINS: THEIR ORIGIN AND SIGNIFICANCE
The significance of the changes that occur in the serum glycoproteins is fundamentally related to their origin. If a clear concept of the origin of these compounds existed, the question of theirExpand
SERUM GLYCOPROTEINS IN INFECTIOUS AND INFLAMMATORY DISEASES *
TLDR
To compare quantitative and electrophoretic variations of certain glycoproteins in clinically discrete diagnostic categories and to compare these glycoprotein variations to those of C-reactive protein, a nonspecific measure of the idammatory response widely used in clinical medicine. Expand
Serum Fucose Levels During Pregnancy and While Taking Oral Contraceptives
TLDR
Both glucose and insulin levels were altered by the two conditions studied, but the serum fucose was not, and while the glucose and diabetes levels fluctuated with time, the serumfucose levels were constant. Expand
...
1
2
...