Utility of serum protein-bound neutral hexoses and L-fucose for estimation of malignant tumor extension and evaluation of efficacy of therapy.
@article{Evans1974UtilityOS, title={Utility of serum protein-bound neutral hexoses and L-fucose for estimation of malignant tumor extension and evaluation of efficacy of therapy.}, author={A S Evans and Melissa Dolan and Philip Z. Sobocinski and Fred A. Quinn}, journal={Cancer research}, year={1974}, volume={34 3}, pages={ 538-42 } }
Summary The method used permits correction for the influence of the neutral hexoses, galactose and mannose, on the apparent concentration of protein-bound l-fucose, as estimated by the Dische-Shettles CyR3 reaction. The values thus obtained, together with the serum concentrations of neutral hexoses, were evaluated in a series of patients, 109 of whom had confirmed diagnoses of cancer. In patients sampled prior to definitive treatment, 89.2% (74 of 83) had elevated ratios of fucose to protein…
27 Citations
Serum protein‐bound carbohydrates and small cell carcinoma of the lung correlations with extent of disease, tumor burden, survival, and clinical response categories
- MedicineCancer
- 1983
The biomarker index was found to be directly correlated with extent of primary disease, number of metastic sites, tumor burden, and clinical response categories assessed at serial time points.
Fucosylated forms of alpha-1-antitrypsin that predict unresponsiveness to chemotherapy in ovarian cancer.
- Medicine, BiologyBritish Journal of Cancer
- 1988
Modified fucosylation of alpha 1-antitrypsin (F-AT) in the sera of ovarian cancer patients found to be particularly associated with the presence of liver metastases and frequently predated any clinical signs of a recurrence.
Correlations among serum protein‐bound carbohydrates, serum glycoproteins, lymphocyte reactivity, and tumor burden in cancer patients
- Biology, MedicineCancer
- 1977
The results suggest that serum protein‐bound carbohydrates or glycoproteins may be of adjunctive value in assessing tumor burden and immune reactivity in cancer patients.
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- Medicine, BiologyThe International journal of biological markers
- 1991
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D-Mannose in human serum, measured as its aldononitrile acetate derivative.
- ChemistryClinical chemistry
- 1979
The sensitivity was such that 10 mg/L could be detected in a 0.1-mL sample of serum, and this method may be of use in diagnosing invasive Candida infection.
Biologic markers in breast carcinoma. IV. Serum fucose‐protein ratio. Comparisons with carcinoembryonic antigen and human chorionic gonadotrophin
- Medicine, BiologyCancer
- 1978
Preliminary data indicate both serum fucose‐protein ratio and CEA frequently become elevated when patients progress from a disease free interval after surgery to recurrence.
Quantitative gas-liquid chromatography of neutral sugars in human serum glycoproteins. Fucose, mannose, and galactose as predictors in ovarian and small cell lung carcinoma.
- Chemistry, BiologyJournal of chromatography
- 1979
Correlation of serum levo - fucose levels among patients with oral squamous cell carcinoma, oral potentially malignant disorders and healthy controls
- Medicine
- 2018
BACK GROUND:
Oral cancer (OC) is one of the major health hazards in India, and approximately 80,000 new cases are diagnosed annually, mainly attributed to different forms of tobacco consumption.…
The structural relationship of blood group-related oligosaccharides in human carcinoma to biological function: A perspective
- BiologyCancer and Metastasis Reviews
- 2004
Blood group-related oligosaccharides have been isolated from a limited number of carcinomas and show chain elongation, for example due to repeating Gal 1,4 GlcNAc 1,3 sequences, or a higher degree of branching, which permit increased sialylation and fucosylation.
Terminal sugars in glycoconjugates: metabolism of free and protein-bound L-fucose, N-acetylneuraminic acid and D-galactose in liver and Morris hepatomas.
- Biology, ChemistryAdvances in experimental medicine and biology
- 1977
The specific activity of α-L-fucosidase in hepatomas with a short or intermediate growth rate was 2 to 7-fold higher than in normal liver, the level of neuraminidase and galactosid enzyme lowered or at least remained unchanged, and a fucoprotein with a molecular weight of about 130,000 has been isolated from both liver and hepatoma plasma membranes.
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