• Corpus ID: 2270556

Utility of serum protein-bound neutral hexoses and L-fucose for estimation of malignant tumor extension and evaluation of efficacy of therapy.

@article{Evans1974UtilityOS,
  title={Utility of serum protein-bound neutral hexoses and L-fucose for estimation of malignant tumor extension and evaluation of efficacy of therapy.},
  author={A S Evans and Melissa Dolan and Philip Z. Sobocinski and Fred A. Quinn},
  journal={Cancer research},
  year={1974},
  volume={34 3},
  pages={
          538-42
        }
}
Summary The method used permits correction for the influence of the neutral hexoses, galactose and mannose, on the apparent concentration of protein-bound l-fucose, as estimated by the Dische-Shettles CyR3 reaction. The values thus obtained, together with the serum concentrations of neutral hexoses, were evaluated in a series of patients, 109 of whom had confirmed diagnoses of cancer. In patients sampled prior to definitive treatment, 89.2% (74 of 83) had elevated ratios of fucose to protein… 

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References

SHOWING 1-10 OF 27 REFERENCES

Partial Characterization of Carbohydrate Residues of Serum Glycoproteins in Neoplastic Disease

Data are presented which confirm reported increases in levels of serum fucose in certain malignancies and indicate that these increases may be attributed to quantitative alterations in specific serum glycoproteins observed in the glycoprotein profile associated with cancer.

Plasma Glycoproteins in Various Disease States Including Carcinoma

Serial determinations of the plasma protein-bound galactose-mannose of the neutral glycoprotein fraction during treatment would suggest that the changes observed in these carbohydrates are intimately related to the neoplastic process.

Serum fucose in the diagnosis of breast cancer

In a total of 300 patients admitted to the hospital with undiagnosed breast masses, there was a definite relationship between higher concentrations of protein‐bound fucose and the presence of breast cancer.

Serum protein-bound fucose levels in certain chronic diseases. A clinical-statistical study.

Determination of L-Fucose in Glycoproteins. I. Effect of Nonfucose Moieties of Serum Glycoproteins

Abstract : The effect of galactose, mannose, and tryptophan on the determination of the methylpentose L-fucose in glycoproteins by the cysteine-sulfuric acid reaction is described. Under certain

Serum Protein‐Bound Fucose in Patients with Gynecologic Cancers

Serum protein-bound fucose levels were not influenced by precedent therapy and correlated well with the clinical stage of squamous-cell carcinoma of the cervix, which was found to be exceedingly helpful in establishing the presence of and in evaluating the extent of recurrent cervical cancer.

Serum fucose levels during pregnancy and while taking oral contraceptives.

There was no significant change in the fasting serum fucose level during pregnancy or during oral contraceptive therapy, and glucose and insulin levels were altered by the 2 conditions studied.

SERUM GLYCOPROTEINS: THEIR ORIGIN AND SIGNIFICANCE

The significance of the changes that occur in the serum glycoproteins is fundamentally related to their origin. If a clear concept of the origin of these compounds existed, the question of their

SERUM GLYCOPROTEINS IN INFECTIOUS AND INFLAMMATORY DISEASES *

To compare quantitative and electrophoretic variations of certain glycoproteins in clinically discrete diagnostic categories and to compare these glycoprotein variations to those of C-reactive protein, a nonspecific measure of the idammatory response widely used in clinical medicine.

Serum Fucose Levels During Pregnancy and While Taking Oral Contraceptives

Both glucose and insulin levels were altered by the two conditions studied, but the serum fucose was not, and while the glucose and diabetes levels fluctuated with time, the serumfucose levels were constant.