• Corpus ID: 2270556

Utility of serum protein-bound neutral hexoses and L-fucose for estimation of malignant tumor extension and evaluation of efficacy of therapy.

@article{Evans1974UtilityOS,
  title={Utility of serum protein-bound neutral hexoses and L-fucose for estimation of malignant tumor extension and evaluation of efficacy of therapy.},
  author={A S Evans and Melissa Dolan and Philip Z. Sobocinski and Fred A. Quinn},
  journal={Cancer research},
  year={1974},
  volume={34 3},
  pages={
          538-42
        }
}

• A. S. Evans, M. Dolan, +1 author F. Quinn
• Published 1 March 1974
• Medicine
• Cancer research

Summary The method used permits correction for the influence of the neutral hexoses, galactose and mannose, on the apparent concentration of protein-bound l-fucose, as estimated by the Dische-Shettles CyR3 reaction. The values thus obtained, together with the serum concentrations of neutral hexoses, were evaluated in a series of patients, 109 of whom had confirmed diagnoses of cancer. In patients sampled prior to definitive treatment, 89.2% (74 of 83) had elevated ratios of fucose to protein and were later found to have metastatic disease. Of those in whom metastasis was positively demonstrated, 94.4% (68 of 72) had elevated values. All patients who were not responding satisfactorily to therapy were elevated in both neutral hexoses and fucose, while those with clinically quiescent tumors and those without demonstrable tumor burden tended to the normal range.