Utility of rat liver S9 fractions to study skin-sensitizing prohaptens in a modified KeratinoSens assay.

@article{Natsch2013UtilityOR,
  title={Utility of rat liver S9 fractions to study skin-sensitizing prohaptens in a modified KeratinoSens assay.},
  author={Andreas Natsch and Tina Haupt},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2013},
  volume={135 2},
  pages={356-68}
}
Prohaptens are chemicals, which may cause skin sensitization after being converted into electrophilic molecules by skin enzymes. Aroclor-induced rat liver S9 fractions represent the metabolic activation system most commonly used in in vitro toxicology. This system contains much higher enzyme activities compared with those reported in skin, but it may still serve as a surrogate system to study the potential of chemicals to act as prohaptens. To test this concept, the luciferase induction in… CONTINUE READING

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