Utility of intraperitoneal administration as a route of AAV serotype 5 vector-mediated neonatal gene transfer.

@article{Ogura2006UtilityOI,
  title={Utility of intraperitoneal administration as a route of AAV serotype 5 vector-mediated neonatal gene transfer.},
  author={Tsuyoshi Ogura and Hiroaki Mizukami and Jun Mimuro and Seiji Madoiwa and Takashi Okada and Takashi Matsushita and Masashi Urabe and Akihiro Kume and Hiromi Hamada and Hiroyuki Yoshikawa and Yoichi Sakata and Keiya Ozawa},
  journal={The journal of gene medicine},
  year={2006},
  volume={8 8},
  pages={990-7}
}
BACKGROUND Gene transfer into a fetus or neonate can be a fundamental approach for treating genetic diseases, particularly disorders that have irreversible manifestations in adulthood. Although the potential utility of this technique has been suggested, the advantages of neonatal gene transfer have not been widely investigated. Here, we tested the usefulness of neonatal gene transfer using adeno-associated virus (AAV) vectors by comparing the administration routes and vector doses. METHODS To… CONTINUE READING
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