Utility of immunohistochemistry in separating thymic neoplasms from germ cell tumors and metastatic lung cancer involving the anterior mediastinum.

@article{Saad2003UtilityOI,
  title={Utility of immunohistochemistry in separating thymic neoplasms from germ cell tumors and metastatic lung cancer involving the anterior mediastinum.},
  author={Reda S. Saad and Rodney J. Landreneau and Yulin L Liu and Jan F. Silverman},
  journal={Applied immunohistochemistry & molecular morphology : AIMM},
  year={2003},
  volume={11 2},
  pages={107-12}
}
A variety of primary and metastatic neoplasms can involve the anterior mediastinum and have similar radiographic or histologic appearances. We report an immunohistochemical (IHC) panel that includes CD5, placental-like alkaline phosphatase (PLAP), thyroid transcription factor 1 (TTF-1), cytokeratin (CK) 7, CK20, CK5/6, and CD57 for the separation of thymic neoplasms from germ cell tumors (GCTs) and metastatic lung malignancies. One hundred cases representing different types of neoplasms… CONTINUE READING

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