Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws.

@article{Freiberger2009UtilityOH,
  title={Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws.},
  author={J J Freiberger},
  journal={Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons},
  year={2009},
  volume={67 5 Suppl},
  pages={96-106}
}
Bisphosphonates suppress bone turnover by disrupting osteoclast signal transduction, maturation, and longevity. In some patients, it has been hypothesized that suppressed turnover can impair oral wound healing, leading to a distressing, osteopetrosis-like jaw necrosis called bisphosphonate-related osteonecrosis of the jaws (BRONJ). Hyperbaric oxygen (HBO), as an adjunct to surgery and antibiotics, might have utility in the treatment of BRONJ because it produces reactive oxygen and nitrogen… CONTINUE READING
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