Utility of composite reference standards and latent class analysis in evaluating the clinical accuracy of diagnostic tests for pertussis.

@article{Baughman2008UtilityOC,
  title={Utility of composite reference standards and latent class analysis in evaluating the clinical accuracy of diagnostic tests for pertussis.},
  author={Andrew L. Baughman and Kristine M. Bisgard and Margaret M. Cortese and William W. Thompson and Gary Noble Sanden and Peter M. Strebel},
  journal={Clinical and vaccine immunology : CVI},
  year={2008},
  volume={15 1},
  pages={
          106-14
        }
}
Numerous evaluations of the clinical sensitivity and specificity of PCR and serologic assays for Bordetella pertussis have been hampered by the low sensitivity of culture, the gold standard test, which leads to biased accuracy estimates. The bias can be reduced by using statistical approaches such as the composite reference standard (CRS) (e.g., positive if culture or serology positive; negative otherwise) or latent class analysis (LCA), an internal reference standard based on a statistical… CONTINUE READING

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