Utility of a rectal suppository containing the antiepileptic drug zonisamide.

@article{Nagatomi1997UtilityOA,
  title={Utility of a rectal suppository containing the antiepileptic drug zonisamide.},
  author={Akiyoshi Nagatomi and Masayuki Mishima and O Tsuzuki and Shigehiro Ohdo and Shouta Higuchi},
  journal={Biological & pharmaceutical bulletin},
  year={1997},
  volume={20 8},
  pages={892-6}
}
A suppository of zonisamide (ZNS) was investigated from the viewpoint of pharmaceutical evaluation, pharmacokinetics and pharmacological effect. Two types of ZNS suppositories were prepared. One used Witepsol (H-15:S-55 = 3:1) as a lipophilic base and the other polyethylene glycol (PEG, 4000:1500 = 4:1) as a hydrophilic base. The in vitro release rate of ZNS from the PEG suppository was significantly rapid compared with that of ZNS from Witepsol. Male Wistar rats were administered ZNS (20 mg/kg… CONTINUE READING