Utility of TK/GCV in the context of highly effective oncolysis mediated by a serotype 3 receptor targeted oncolytic adenovirus

@article{Raki2007UtilityOT,
  title={Utility of TK/GCV in the context of highly effective oncolysis mediated by a serotype 3 receptor targeted oncolytic adenovirus},
  author={Mari Raki and Tanja Hakkarainen and Gerd Johannes Bauerschmitz and Merja S{\"a}rkioja and Renee Ann Desmond and Anna Kanerva and Akseli Hemminki},
  journal={Gene Therapy},
  year={2007},
  volume={14},
  pages={1380-1388}
}
Arming oncolytic adenoviruses with therapeutic transgenes and enhancing transduction of tumor cells are useful strategies for eradication of advanced tumor masses. Herpes simplex virus thymidine kinase (TK) together with ganciclovir (GCV) has been promising when coupled with viruses featuring low oncolytic potential, but their utility is unknown in the context of highly effective infectivity-enhanced viruses. We constructed Ad5/3-Δ24-TK-GFP, a serotype 3 receptor-targeted, Rb/p16 pathway… CONTINUE READING