Utility of DNA postreplication repair protein Rad6B in neoadjuvant chemotherapy response.

@article{Shekhar2010UtilityOD,
  title={Utility of DNA postreplication repair protein Rad6B in neoadjuvant chemotherapy response.},
  author={Malathy P. V. Shekhar and Laura A. Biernat and Nat L. Pernick and Larry R Tait and Judith Abrams and Daniel W. Visscher},
  journal={Medical oncology},
  year={2010},
  volume={27 2},
  pages={466-73}
}
Neoadjuvant chemotherapy is a standard therapy for patients with locally advanced breast cancer (LABC) and is increasingly used for early stage operable breast cancer. Not all patients benefit from it, and reliable markers for predicting response are needed. The cytotoxic effects of chemotherapy are mediated by induction of DNA damage in tumor cells. There is evidence that resistance to chemotherapy is related to enhanced repair of DNA lesions. The postreplication DNA repair (PRR) or… CONTINUE READING