Utility of BRAF protein overexpression in predicting the metastasis potential of papillary thyroid carcinoma.

@article{Feng2011UtilityOB,
  title={Utility of BRAF protein overexpression in predicting the metastasis potential of papillary thyroid carcinoma.},
  author={Linhui Feng and Mei Li and Qiu-ping Zhang and Zheng-Ai Piao and Zhaohui Wang and Shen Juan Lv},
  journal={Oncology letters},
  year={2011},
  volume={2 1},
  pages={
          59-63
        }
}
V-raf murine sarcoma viral oncogene homolog B1 (BRAF) is a significant member of the MAPK pathway, the point mutation (V600E) of which is a common genetic event in papillary thyroid carcinoma (PTC). Investigators showed that the variations in BRAF expression levels were independent of the V600E mutation. These variations were involved in the pathogenesis of thyroid carcinomas. This study evaluated the feasibility of BRAF, proliferating cell nuclear antigen (PCNA) and hMSH2 as markers for the… CONTINUE READING

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