Utility of Acetylcysteine in Treating Poisonings and Adverse Drug Reactions

  title={Utility of Acetylcysteine in Treating Poisonings and Adverse Drug Reactions},
  author={Peter A. Chyka and Adrianne Y. Butler and Billie J. Holliman and Martin I. Herman},
  journal={Drug Safety},
  • Peter A. ChykaA. Butler M. Herman
  • Published 2000
  • Medicine, Biology, Chemistry
  • Drug Safety
As recognition of the role of free radicals and reactive toxins in the pathogenesis of disease, poisoning, and adverse drug reactions has evolved, interest in the use of acetylcysteine as a modulator of these effects has steadily increased in recent years. Acetylcysteine is commonly thought to serve as a glutathione precursor and consequently can increase or sustain intracellular glutathione which scavenges reactive oxygen species caused by toxins or subsequent tissue injury. At least 10… 

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There is enough evidence that the proper use of specific antidotes when combined with general supportive care does reduce the morbidity and mortality associated with severe poisonings.

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  • A. Jones
  • Medicine, Biology
    Journal of toxicology. Clinical toxicology
  • 1998
While there is a trend suggesting a beneficial effect of N- acetylcysteine in some patients presenting beyond 15 hours, further research is necessary to establish just how effective N-acetylcy Steine is, particularly in patients presenting with fulminant hepatic failure.

Use of N-acetylcysteine in clinical toxicology.

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