Utilising structural knowledge in drug design strategies: applications using Relibase.

@article{Gnther2003UtilisingSK,
  title={Utilising structural knowledge in drug design strategies: applications using Relibase.},
  author={Judith G{\"u}nther and Andreas Bergner and Manfred Hendlich and Gerhard Klebe},
  journal={Journal of molecular biology},
  year={2003},
  volume={326 2},
  pages={
          621-36
        }
}
The concept of structure-based drug design is based upon an in-depth understanding of the principles of molecular recognition. Despite our lack of a thorough comprehension of these principles, the wealth of protein structures available opens up unprecedented possibilities for new insights from the analysis of these data. Unravelling universal rules of molecular recognition is certainly one of the most appealing goals. But our knowledge is enhanced also when studying the specific determinants… CONTINUE READING
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