Uterus Transplant

@article{Nair2008UterusT,
  title={Uterus Transplant},
  author={Anjana R. Nair and Jeanetta Stega and J. Richard Smith and Giuseppe del Priore},
  journal={Annals of the New York Academy of Sciences},
  year={2008},
  volume={1127}
}
Absolute uterine infertility affects millions of women in the United States and more throughout the world. For instance, each year in the United States about 5,000 hysterectomies are performed in women under the age of 24. In total, nearly 9 million women of reproductive age have had a hysterectomy. Based on fecundity rates, thousands of these women may be candidates for uterus transplantation. An ongoing study enrolling some of these potential recipients onto a uterus transplant “waiting list… 

Uterine Transplantation: An Option beyond Surrogacy

Considering the large number of hysterectomies done all over the world and uteruses available for transplantation, uterine transplant has potential to surpass, in numbers, the other transplant in near future.

Ethical considerations in uterus transplantation

Given that uterus transplantation brings together the challenges of both assisted reproductive technology as well as organ transplantation as the world’s first ephemeral transplant, it is important to discuss the ethical, legal, and social implications prior to moving from research to widespread clinical practice.

Experimental uterus transplantation.

Uterine transplantation--a real possibility? The Indianapolis consensus.

A group of experts gathered in Indianapolis in December 2011 to address lingering concerns related to uterus transplantation (UTn) and presented here are a set of parameters that must be considered in order for UTn to become an acceptable procedure in the human setting.

Uterus transplantation: ethical considerations

Clinical trial results provides a basis for weighing the interests of the stakeholders implicated in Utx, and can inform transplant centers’ and regulatory bodies’ development of policies and protocols that will determine access to Utx and allocation of organs, together with other considerations of justice.

Uterus Transplantation and Surrogacy in Japan: a Country in which Surrogacy is Prohibited

The responses of the Japanese maternal nurse students are evaluated, the current status and restrictions on surrogacy in Japan are discussed and uterine implantation is discussed.

The Ethics of Uterus Transplantation: Moral Challenges and Recommendations for Progress

The ethical concerns regarding whether the pursuit of a pregnancy justifies the risks involved with the surgery must now be updated to acknowledge the successes and failures of these first attempts of uterus transplants.

Immunology of Uterine Transplantation

Uterus transplantation (UTn) has been proposed as another quality-of-life transplant for the cure of permanent uterine factor infertility and a greater appreciation of the immunological mechanisms that underlie UTn is desirable.

Uterus transplantation: ethical and regulatory challenges

It is important to address questions regarding the physical, psychosocial and ethical risks and benefits of uterus transplantation for all three parties involved—the patient, the donor and the potential child—as well as discuss the regulatory implications as research on uterus transplantations moves forward.

UK criteria for uterus transplantation: a review

Recommendations advanced include the use of donor eggs, access for single women and women in same‐sex relationships, prohibiting participation of women who are already mothers, and a preference for deceased donors and bioengineered uteri.

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A broad history of transplantation in the male and female genital tracts as well as attempts to anticipate possible future developments are presented.

Replantation of uterus and ovaries in dogs, with successful pregnancy.

These studies apparently represent the first in which vascular anastomoses were used for successful uterine replantation and were supported by aortography, hysterography, studies of vaginal epithelium, and evidence of ovulation.

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The human uterus can be obtained from local organ donor networks using existing protocols and there are no signs of change over 12 hours of cold ischemia.

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Recently, a team of physicians at the New York Downtown Hospital announced they had received approval from their institutional review board to attempt the first uterus transplant in the world from a cadaver donor, which would allow the recipient to give birth.

Pelvic vascular prospects for uterine transplantation.

Uterine arteryAnastomosis in the porcine model is feasible with subsequent normal vascular function in pregnancy of the anastomosed vessels with minimal intimal fibrosis across all anastsomotic sites.

Drug Safety Issues in Pregnancy Following Transplantation and Immunosuppression

Current data from the literature, as well as from reports from the National Transplantation Pregnancy Registry, support the concept that immuno suppression be maintained at appropriate levels during pregnancy.

Laryngeal and tracheal transplantation: ethical limitations.

Over the last decade, there have been extraordinary developments in the field of transplantation science. As a result, organ transplantation enjoys a success that is unparalleled since its

Abdominal Radical Trachelectomy During Pregnancy to Preserve Pregnancy and Fertility

Pregnancy complicated by concurrent cervical cancer can be managed with abdominal radical trachelectomy during pregnancy while preserving future fertility, according to a small number of patients.
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