Uterus Transplant

@article{Nair2008UterusT,
  title={Uterus Transplant},
  author={Anjana R. Nair and Jeanetta Stega and J. Richard Smith and Giuseppe del Priore},
  journal={Annals of the New York Academy of Sciences},
  year={2008},
  volume={1127}
}
Absolute uterine infertility affects millions of women in the United States and more throughout the world. For instance, each year in the United States about 5,000 hysterectomies are performed in women under the age of 24. In total, nearly 9 million women of reproductive age have had a hysterectomy. Based on fecundity rates, thousands of these women may be candidates for uterus transplantation. An ongoing study enrolling some of these potential recipients onto a uterus transplant “waiting list… 
Uterine Transplantation: An Option beyond Surrogacy
TLDR
Considering the large number of hysterectomies done all over the world and uteruses available for transplantation, uterine transplant has potential to surpass, in numbers, the other transplant in near future.
Uterus transplantation An experimental study in primates
TLDR
Autologous and allogeneic UTx have been demonstrated in a nonhuman primate model proving to be a donor and recipient safe surgical procedure, regardless whether the graft is from a live or a deceased donor.
Experimental uterus transplantation.
TLDR
Research in the field of uterus transplantation has been evaluated in different animal models for decades and has presently reached a human clinical application as a possible treatment for absolute uterine factor infertility.
Uterine transplantation--a real possibility? The Indianapolis consensus.
TLDR
A group of experts gathered in Indianapolis in December 2011 to address lingering concerns related to uterus transplantation (UTn) and presented here are a set of parameters that must be considered in order for UTn to become an acceptable procedure in the human setting.
Uterus Transplantation and Surrogacy in Japan: a Country in which Surrogacy is Prohibited
TLDR
The responses of the Japanese maternal nurse students are evaluated, the current status and restrictions on surrogacy in Japan are discussed and uterine implantation is discussed.
The Ethics of Uterus Transplantation: Moral Challenges and Recommendations for Progress
TLDR
The ethical concerns regarding whether the pursuit of a pregnancy justifies the risks involved with the surgery must now be updated to acknowledge the successes and failures of these first attempts of uterus transplants.
Immunology of Uterine Transplantation
TLDR
Uterus transplantation (UTn) has been proposed as another quality-of-life transplant for the cure of permanent uterine factor infertility and a greater appreciation of the immunological mechanisms that underlie UTn is desirable.
Uterus transplantation: ethical and regulatory challenges
TLDR
It is important to address questions regarding the physical, psychosocial and ethical risks and benefits of uterus transplantation for all three parties involved—the patient, the donor and the potential child—as well as discuss the regulatory implications as research on uterus transplantations moves forward.
UK criteria for uterus transplantation: a review
TLDR
Recommendations advanced include the use of donor eggs, access for single women and women in same‐sex relationships, prohibiting participation of women who are already mothers, and a preference for deceased donors and bioengineered uteri.
Revaluation and lessons learned from the first 9 cases of a Czech uterus transplantation trial: Four deceased donor and 5 living donor uterus transplantations
  • R. Chmel, M. Novackova, +7 authors J. Fronek
  • Medicine
    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2019
TLDR
The main characteristics and perioperative and postoperative courses of both recipients and donors following 4 deceased donor and 5 living donor uterus transplantations are reported.
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References

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  • W. Fageeh, H. Raffa, H. Jabbad, A. Marzouki
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2002
TLDR
Human uterine transplantation was performed on a 26‐year‐old female who lost her uterus 6 years earlier due to post‐partum hemorrhage and she developed acute vascular thrombosis 99 days after transplantation, and hysterectomy was necessary.
Transplantation in reproductive medicine: previous experience, present knowledge and future prospects.
TLDR
A broad history of transplantation in the male and female genital tracts as well as attempts to anticipate possible future developments are presented.
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TLDR
Pregnancy is no longer contraindicated in cancer patients including breast and endometrial cancer survivors and informed patients are offered every possible option, including ART and uterine transplantation, to achieve their family planning objectives.
Replantation of uterus and ovaries in dogs, with successful pregnancy.
TLDR
These studies apparently represent the first in which vascular anastomoses were used for successful uterine replantation and were supported by aortography, hysterography, studies of vaginal epithelium, and evidence of ovulation.
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TLDR
The human uterus can be obtained from local organ donor networks using existing protocols and there are no signs of change over 12 hours of cold ischemia.
Moving the Womb
TLDR
Recently, a team of physicians at the New York Downtown Hospital announced they had received approval from their institutional review board to attempt the first uterus transplant in the world from a cadaver donor, which would allow the recipient to give birth.
Uterine transplantation in humans: a new frontier
  • L. Keith, G. Del Priore
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2002
TLDR
The editors of the International Journal of Gynecology and Obstetrics are pleased that Drs Fageeh, Raffa, Jabbad and Marzouki have chosen this journal to present their report on the first human uterine transplantation, which presents in detail a thorough discussion of the preparatory animal experimentation and surgical techniques refined.
A fertility-sparing alternative to radical hysterectomy: how many patients may be eligible?
TLDR
A significant number of patients < 40 with early-stage cervical cancer may be pathologically eligible for LRVT and should be counseled on this preoperatively.
Pelvic vascular prospects for uterine transplantation.
TLDR
Uterine arteryAnastomosis in the porcine model is feasible with subsequent normal vascular function in pregnancy of the anastomosed vessels with minimal intimal fibrosis across all anastsomotic sites.
Drug Safety Issues in Pregnancy Following Transplantation and Immunosuppression
TLDR
Current data from the literature, as well as from reports from the National Transplantation Pregnancy Registry, support the concept that immuno suppression be maintained at appropriate levels during pregnancy.
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