Uterine stimulant action of some 16-phenoxy analogues of (+)-11-deoxyprostaglandin E1.

Abstract

Some (+)-11-deoxy-16-phenoxyprostaglandin E1 analogues have been evaluated as uterine stimulants in the anaesthetised pregnant rat. Gastrointestinal side effects, assessed by the antagonism of morphine-induced constipation in the mouse, were relatively low with some of these compounds, six of which had a much more favourable relative selectivity than 16,16-dimethyl-PGE2 methyl ester.

Cite this paper

@article{Caton1984UterineSA, title={Uterine stimulant action of some 16-phenoxy analogues of (+)-11-deoxyprostaglandin E1.}, author={M. P. Caton and Elizabeth Coffee and David Hambling and Charlotte J Hardy and M N Palfreyman}, journal={Prostaglandins}, year={1984}, volume={27 5}, pages={761-70} }