Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice.

@article{Hirota2010UterinespecificPD,
  title={Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice.},
  author={Yasushi Hirota and Takiko Daikoku and Susanne L Tranguch and Huirong Xie and Heather B. Bradshaw and Sudhansu K Dey},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 3},
  pages={803-15}
}
Many signaling pathways that contribute to tumorigenesis are also functional in pregnancy, although they are dysregulated in the former and tightly regulated in the latter. Transformation-related protein 53 (Trp53), which encodes p53, is a tumor suppressor gene whose mutation is strongly associated with cancer. However, its role in normal physiological processes, including female reproduction, is poorly understood. Mice that have a constitutive deletion of Trp53 exhibit widespread development… CONTINUE READING
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