Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs.

@article{Prizant2013UterinespecificLO,
  title={Uterine-specific loss of Tsc2 leads to myometrial tumors in both the uterus and lungs.},
  author={Hen Prizant and Aritro Sen and Allison Light and Sung-nam Cho and Francesco J. Demayo and John P Lydon and Stephen R. Hammes},
  journal={Molecular endocrinology},
  year={2013},
  volume={27 9},
  pages={
          1403-14
        }
}
Lymphangioleiomyomatosis (LAM) is a rare disease characterized by proliferation of abnormal smooth-muscle cells in the lungs, leading to functional loss and sometimes lung transplantation. Although the origin of LAM cells is unknown, several features of LAM provide clues. First, LAM cells contain inactivating mutations in genes encoding Tsc1 or Tsc2, proteins that limit mTORC1 activity. Second, LAM tumors recur after lung transplantation, suggesting a metastatic pathogenesis. Third, LAM is… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 17 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 71 REFERENCES

Generation of a conditional disruption of the Tsc2 gene. Genesis

  • O Hernandez, S Way, McKenna J 3rd, MJ Gambello
  • 2007
Highly Influential
4 Excerpts

Pregnancy exacerbating unsus doi: 10.1210/me.2013-1059 mend.endojournals.org 1413 The Endocrine Society. Downloaded from press.endocrine.org by [${individualUser.displayName}] on

  • A Brunelli, G Catalini, A. Fianchini
  • For personal use only. No other uses without…
  • 2015

Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a 1412 Prizant et al Tsc2 Loss Leads to Uterus and Lung Tumors

  • M Karbowniczek, A Astrinidis, BR Balsara
  • Mol Endocrinol,
  • 2013
2 Excerpts

Similar Papers

Loading similar papers…