Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses.

@article{Winuthayanon2010UterineEE,
  title={Uterine epithelial estrogen receptor α is dispensable for proliferation but essential for complete biological and biochemical responses.},
  author={Wipawee Winuthayanon and Sylvia C Hewitt and Grant D. Orvis and Richard R. Behringer and Kenneth S. Korach},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 45},
  pages={19272-7}
}
Female fertility requires estrogen to specifically stimulate estrogen receptor α (ERα)-dependent growth of the uterine epithelium in adult mice, while immature females show proliferation in both stroma and epithelium. To address the relative roles of ERα in mediating estrogen action in uterine epithelium versus stroma, a uterine epithelial-specific ERα knockout (UtEpiαERKO) mouse line was generated by crossing Esr mice with Wnt7a-Cre mice. Expression of Wnt7a directed Cre activity generated… CONTINUE READING
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