Uterine carcinosarcoma is derived from a single stem cell: an in vitro study.

@article{Gorai1997UterineCI,
  title={Uterine carcinosarcoma is derived from a single stem cell: an in vitro study.},
  author={Itsuo Gorai and Tsutomu Yanagibashi and Arihiro Taki and Kiyoshi Udagawa and Etsuko Miyagi and Tsutomu Nakazawa and Fumiki Hirahara and Yoji Nagashima and Hiroshi Minaguchi},
  journal={International journal of cancer},
  year={1997},
  volume={72 5},
  pages={821-7}
}
Expression of intermediate filaments (IFs) has been suggested to be a reliable marker for differentiating epithelial and non-epithelial tumors. Moreover, the c-erbB-2 and p53 genes are considered to be involved relatively early in the process of human carcinogenesis. In order to elucidate the origin of uterine carcinosarcomas, we analyzed IF, c-erbB-2 and p53 expression in and the ultrastructural characteristics of clones derived from a human uterine-carcinosarcoma cell line, EMTOKA. The… CONTINUE READING