Uterine artery structural and functional changes during pregnancy in tissue kallikrein-deficient mice.

@article{Hilgers2003UterineAS,
  title={Uterine artery structural and functional changes during pregnancy in tissue kallikrein-deficient mice.},
  author={Rob H. P. Hilgers and Sonia Bergaya and Paul M. H. Schiffers and Pierre Meneton and Chantal M Boulanger and Daniel Henrion and Bernard I L{\'e}vy and Jo G R De Mey},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2003},
  volume={23 10},
  pages={
          1826-32
        }
}
OBJECTIVE Tissue kallikrein (TK) participates in acute flow-induced dilatation (FID) of large arteries. We investigated whether TK deficiency blunts FID and alters chronic flow-related arterial structural and functional changes in resistance-sized muscular arteries. METHODS AND RESULTS Vasomotor responses and structural parameters were determined in uterine arteries isolated from nonpregnant, 18- to 19-day pregnant, and 7-day postpartum TK-/- and TK+/+ littermate mice. In TK-/- mice, values… CONTINUE READING

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