Uterine Wnt/beta-catenin signaling is required for implantation.

  title={Uterine Wnt/beta-catenin signaling is required for implantation.},
  author={Othman A. Mohamed and Maud Jonnaert and Cassandre Labelle-Dumais and Kazuki Kuroda and Hugh J Clarke and Daniel Dufort},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 24},
Successful implantation relies on precisely orchestrated and reciprocal signaling between the implanting blastocyst and the receptive uterus. We have examined the role of the Wnt/beta-catenin signaling pathway during the process of implantation and demonstrate that this pathway is activated during two distinct stages. Wnt/beta-catenin signaling is first transiently activated in circular smooth muscle forming a banding pattern of activity within the uterus on early day 4. Subsequently… CONTINUE READING

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