Ustekinumab demonstrates activity in glucocorticoid-refractory acute GVHD

Abstract

Novel approaches are needed for GVHD prophylaxis and therapy. Naive CD4þ T cells differentiate into distinct lineages (Th1, Th2, Th17, Treg) under the influence of APCs and specific cytokine programs. Data suggest unique contributions of these CD4þ T-cell subsets to the target manifestations of GVHD. Donor Th1 CD4þ T cells have a central role in the… (More)
DOI: 10.1038/bmt.2011.172

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