Usp18 regulates epidermal growth factor (EGF) receptor expression and cancer cell survival via microRNA-7.

@article{Duex2011Usp18RE,
  title={Usp18 regulates epidermal growth factor (EGF) receptor expression and cancer cell survival via microRNA-7.},
  author={Jason E. Duex and Laurey Comeau and Alexander Sorkin and Benjamin Purow and Benjamin Kefas},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 28},
  pages={25377-86}
}
Epidermal growth factor receptor (EGFR) is involved in development and progression of many human cancers. We have previously demonstrated that the ubiquitin-specific peptidase Usp18 (Ubp43) is a potent regulator of EGFR protein expression. Here we report that the 3'-untranslated region (3'-UTR) of the EGFR message modulates RNA translation following cell… CONTINUE READING

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