Using the transcriptome to annotate the genome

@article{Saha2002UsingTT,
  title={Using the transcriptome to annotate the genome},
  author={Saurabh Saha and Andrew B. Sparks and Carlo Rago and Viatcheslav R. Akmaev and Clarence J. Wang and Bert Vogelstein and Kenneth W. Kinzler and Victor E. Velculescu},
  journal={Nature Biotechnology},
  year={2002},
  volume={20},
  pages={508-512}
}
A remaining challenge for the human genome project involves the identification and annotation of expressed genes. The public and private sequencing efforts have identified ∼15,000 sequences that meet stringent criteria for genes, such as correspondence with known genes from humans or other species, and have made another ∼10,000–20,000 gene predictions of lower confidence, supported by various types of in silico evidence, including homology studies, domain searches, and ab initio gene… CONTINUE READING
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