Using the tolerable-dose diagram in the design of phase I combination chemotherapy trials.

@article{Korn1993UsingTT,
  title={Using the tolerable-dose diagram in the design of phase I combination chemotherapy trials.},
  author={Edward L. Korn and Richard Simon},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1993},
  volume={11 4},
  pages={794-801}
}
PURPOSE Choosing maximum-tolerated doses (MTDs) of agents to be administered in combination is more complicated than choosing the MTD for a single agent. This is because there are many combinations of doses that will be tolerated. We offer guidance in targeting specific MTD combinations, and suggest trial designs to achieve these targets. METHODS A graphical method based on a simple, previously described mathematical model is used to guide the phase I trial design. The method involves… CONTINUE READING