Using the national cancer institute anticancer drug screen to assess the effect of MRP expression on drug sensitivity profiles.

@article{Alvarez1998UsingTN,
  title={Using the national cancer institute anticancer drug screen to assess the effect of MRP expression on drug sensitivity profiles.},
  author={Marco A. Alvarez and Robert Robey and Victor A Sandor and Kazunori Nishiyama and Yoshiro Matsumoto and Kenneth Paull and Susan Bates and Tito Fojo},
  journal={Molecular pharmacology},
  year={1998},
  volume={54 5},
  pages={802-14}
}
The MRP gene contributes to one form of multidrug resistance. To identify drugs interacting with MRP, we measured MRP mRNA expression by quantitative PCR in 60 cell lines of the National Cancer Institute Anticancer Drug Screen. Expression was detected in all cell lines (highest in lung carcinomas and central nervous system tumors) with a range of 14-fold. A mean graph of MRP mRNA levels was constructed to determine Pearson correlation coefficients (PCCs) with mean graphs of >40,000 compounds… CONTINUE READING
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