Using the heat-shock response to discover anticancer compounds that target protein homeostasis.

@article{Santagata2012UsingTH,
  title={Using the heat-shock response to discover anticancer compounds that target protein homeostasis.},
  author={Sandro S. Santagata and Ya-ming Xu and E. M. Kithsiri Wijeratne and Renee Kontnik and Christine Rooney and Casey C. Perley and Hyoungtae Kwon and Jon Clardy and Santosh Kesari and Luke Whitesell and Susan Lindquist and A A Leslie Gunatilaka},
  journal={ACS chemical biology},
  year={2012},
  volume={7 2},
  pages={340-9}
}
Unlike normal tissues, cancers experience profound alterations in protein homeostasis. Powerful innate adaptive mechanisms, especially the transcriptional response regulated by Heat Shock Factor 1 (HSF1), are activated in cancers to enable survival under these stressful conditions. Natural products that further tax these stress responses can overwhelm the ability to cope and could provide leads for the development of new, broadly effective anticancer drugs. To identify compounds that drive the… CONTINUE READING
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High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.

Proceedings of the National Academy of Sciences of the United States of America • 2011

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