Using the TOPS-MODE approach to fit multi-target QSAR models for tyrosine kinases inhibitors.

@article{Marzaro2011UsingTT,
  title={Using the TOPS-MODE approach to fit multi-target QSAR models for tyrosine kinases inhibitors.},
  author={Giovanni Marzaro and Adriana Chilin and Adriano Guiotto and Eugenio Uriarte and Paola Brun and Ignazio Castagliuolo and Francesca Tonus and Humberto Gonz{\'a}lez-D{\'i}az},
  journal={European journal of medicinal chemistry},
  year={2011},
  volume={46 6},
  pages={2185-92}
}
Tyrosine kinases constitute an eligible class of target for novel drug discovery. They resulted often overexpressed and/or deregulated in several cancer diseases. Thus, the development of novel tyrosine kinases inhibitors is of value, as well as the finding of novel cheminformatic tools for their design. Among the different ways to rationally design novel compounds, the Quantitative Structure-Activity Relationship (QSAR) plays a key role. The QSAR approach, in fact, allow the prediction of… CONTINUE READING

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