Using the Internal Stress Concept to Assess the Importance of Moisture Sorption-induced Swelling on the Moisture Transport through the Glassy HPMC Films

  title={Using the Internal Stress Concept to Assess the Importance of Moisture Sorption-induced Swelling on the Moisture Transport through the Glassy HPMC Films},
  author={Fesia Lestari Laksmana and Paul J. A. Hartman Kok and Henderik W. Frijlink and Herman Vromans and Kees Voort Maarschalk},
  journal={AAPS PharmSciTech},
The purpose of this research was to elucidate the significance of the changes in the mechanical and the volumetric properties on the moisture diffusivity through the polymer films. The internal stress concept was adapted and applied to estimate the relative impact of these property changes on the total stress experienced by a polymer film during storage. Hydroxypropyl Methylcellulose free films were used as a model material prepared at various conditions and stored at different relative… 
Gas Permeation Related to the Moisture Sorption in Films of Glassy Hydrophilic Polymers
The purpose of this article is to elucidate the effect of integral sorption of moisture on gas permeation in glassy hydrophilic polymers. The oxygen and the simultane- ous moisture sorption into
Predicting the diffusion coefficient of water vapor through glassy HPMC films at different environmental conditions using the free volume additivity approach.
The presented approach enables the prediction of the diffusivity at any given relevant material variable and therefore has the potency to be used as a formulation development tool.
Objective: An aqueous-organic precipitation technique was developed for preparing bioadhesive hydroxypropyl methylcellulose (HPMC) microparticles for nasal delivery using a low viscosity grade of
Functional encapsulation of small particles : quantification and control of the morphology of the coating layers : quantification and control of the morphology of the coating layers
In this chapter, an overview of the important aspects of the formulation and the process development of a functional encapsulated product is given. It is shown that there is a need of quantification
Stability and Comparative Dissolution Studies of Five Brands of Norfloxacin Tablets Marketed in Addis Ababa, Ethiopia
The dissolution profiles of five different brands of norfloxacin (400 mg) tablets designated as A, B, C, D, and E, marketed in Addis Ababa were compared with those of an innovator product (F). The


Quantitative estimation of internal stress development in aqueous HPMC tablet film coats
Abstract Data have been produced on the parameters which influence the development of internal stresses within aqueous HPMC film coats plasticized with glycerol in an attempt to calculate the
Effect of particle size and sorbed moisture on the tensile strength of some tableted hydroxypropyl methylcellulose (HPMC) polymers
Abstract The tensile strengths of compacts produced from powdered HPMC polymers with different particle size, methoxy/ hydropropoxy substitution ratio, molecular size and moisture content achieved by
Physical-mechanical, moisture absorption and bioadhesive properties of hydroxypropylcellulose hot-melt extruded films.
The bioadhesive properties of the HPC/PEG 3350 5% film and the polycarbophil 5% containing films, with and without PEG, were investigated in vivo on the human epidermis, showing a greater force of adhesion and elongation at adhesive failure in vivo.
Effects of Tablet Core Dimensional Instability on the Generation of Internal Stresses Within Film Coats
AbstractDimensional changes of tablets compressed from maize starch were measured by means of a free-armature transducer rig under three possible simulated film coating conditions (30°C and 45%RH,
The internal stress of coating films
In organic coatings, serious defects or film failure (cracking, bending and peeling) may be caused by internal stresses which adversely affect adhesive and cohesive properties (elasticity) of the
Observation of swelling process and diffusion front position during swelling in hydroxypropyl methyl cellulose (HPMC) matrices containing a soluble drug.
  • P. Colombo, R. Bettini, N. Peppas
  • Materials Science, Medicine
    Journal of controlled release : official journal of the Controlled Release Society
  • 1999
The physical analysis of swellable hydroxypropyl methyl cellulose matrices loaded with increasing amounts of soluble and colored drug and exhibiting swelling, diffusion and erosion fronts clearly showed the importance of drug solubility and loading in the observation of the diffusion front.
The origin of residual internal stress in solvent‐cast thermoplastic coatings
Experiments on polystyrene and poly(isobutyl methacrylate) coatings cast from toluene have shown that residual internal stress is independent of dried coating thickness and initial solution
Moisture in organic coatings - a review
A review is given on transport and equilibrium sorption of moisture in polymer films and organic coatings. Polymeric material forms the continuous phase of a coating and is therefore important for
The Relationship Between the Glass Transition Temperature and the Water Content of Amorphous Pharmaceutical Solids
It was found that there is a rapid initial reduction in the glass transition temperature from the dry state as water is absorbed, followed by a gradual leveling off of the response at higher water contents, indicating that water acts as a plasticizer in a way similar to that of other small molecules and not through any specific or stoichiometric interaction process(es).
Matrix swelling: A simple model describing extent of swelling of HPMC matrices
Abstract The swelling of HPMC matrices was measured by determining the vertical displacement with time using a dial indicator. Curve fitting of the data of swelling was carried out by using the