Highly Influenced

7 Excerpts

- Published 2012 in PloS one

Using complex roots of unity and the Fast Fourier Transform, we design a new thermodynamics-based algorithm, FFTbor, that computes the Boltzmann probability that secondary structures differ by [Formula: see text] base pairs from an arbitrary initial structure of a given RNA sequence. The algorithm, which runs in quartic time O(n(4)) and quadratic space O(n(2)), is used to determine the correlation between kinetic folding speed and the ruggedness of the energy landscape, and to predict the location of riboswitch expression platform candidates. A web server is available at http://bioinformatics.bc.edu/clotelab/FFTbor/.

Citations per Year

Averaging **8 citations** per year over the last 3 years.

@inproceedings{Senter2012UsingTF,
title={Using the Fast Fourier Transform to Accelerate the Computational Search for RNA Conformational Switches},
author={Evan Senter and Saad Sheikh and Iv{\'a}n Dot{\'u} and Yann Ponty and Peter Clote},
booktitle={PloS one},
year={2012}
}