Using the Auditory Brainstem Response (ABR) to Determine Sensitivity of Hearing in Mutant Mice.

@article{Ingham2011UsingTA,
  title={Using the Auditory Brainstem Response (ABR) to Determine Sensitivity of Hearing in Mutant Mice.},
  author={Neil J. Ingham and Selina A Pearson and Karen P. Steel},
  journal={Current protocols in mouse biology},
  year={2011},
  volume={1 2},
  pages={279-87}
}
Measurements of auditory evoked potentials can be used to determine reliably an audiometric representation of hearing sensitivity in mice. In a high-throughput phenotyping screen of mice carrying targeted mutations of single genes, the auditory brainstem response (ABR) is used to gain an estimate of hearing threshold for broadband click stimuli and pure tone frequencies ranging from 6 to 30 kHz. Comparison of thresholds obtained in mutant and wild-type mice give a means to determine mild… CONTINUE READING
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