Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity.

@article{Strachan2005UsingTP,
  title={Using terahertz pulsed spectroscopy to quantify pharmaceutical polymorphism and crystallinity.},
  author={Clare J Strachan and Philip F. Taday and David A. Newnham and Keith C Gordon and J. Axel Zeitler and Michael Sean Pepper and Thomas Rades},
  journal={Journal of pharmaceutical sciences},
  year={2005},
  volume={94 4},
  pages={837-46}
}
Terahertz pulsed spectroscopy (TPS) is a new technique that is capable of eliciting rich information when investigating pharmaceutical materials. In solids, it probes long-range crystalline lattice vibrations and low energy torsion and hydrogen bonding vibrations. These properties make TPS potentially an ideal tool to investigate crystallinity and polymorphism. In this study four drugs with different solid-state properties were analyzed using TPS and levels of polymorphism and crystallinity… CONTINUE READING
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