Using temporal correlations and full distributions to separate intrinsic and extrinsic fluctuations in biological systems.

@article{Hilfinger2012UsingTC,
  title={Using temporal correlations and full distributions to separate intrinsic and extrinsic fluctuations in biological systems.},
  author={Andreas Hilfinger and Mark Chen and Johan Paulsson},
  journal={Physical review letters},
  year={2012},
  volume={109 24},
  pages={248104}
}
Studies of stochastic biological dynamics typically compare observed fluctuations to theoretically predicted variances, sometimes after separating the intrinsic randomness of the system from the enslaving influence of changing environments. But variances have been shown to discriminate surprisingly poorly between alternative mechanisms, while for other system properties no approaches exist that rigorously disentangle environmental influences from intrinsic effects. Here, we apply the theory of… CONTINUE READING

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