Using synthesized onion lachrymatory factor to measure age-related decreases in reflex-tear secretion and ocular-surface sensation

  title={Using synthesized onion lachrymatory factor to measure age-related decreases in reflex-tear secretion and ocular-surface sensation},
  author={Hisayo Higashihara and Norihiko Yokoi and Morihiro Aoyagi and Nobuaki Tsuge and Shinsuke Imai and Shigeru Kinoshita},
  journal={Japanese Journal of Ophthalmology},
PurposeTo use synthesized onion lachrymatory factor (SOLF) to investigate age-related changes in reflex-tear secretion and ocular-surface sensation. [] Key Result After the SOLF stimulus, corneal sensitivity was examined by Cochet-Bonnet esthesiometry (CB), and reflex-tear secretion was examined by the Schirmer I-test (ST).ResultsTLI was significantly shorter in group A than in the other groups (P < 0.0001), and the groups B and D also differed significantly from each other (P = 0.0013).
Problems of the “Outer Eyes” in the Office Environment: An Ergophthalmologic Approach
The microclimate, environmental pollution, working conditions and habits, contact lenses, certain medication, nutrition, and personal care products alter the PTF, leading to desiccation and hyperosmolarity.
Unresolved clinical needs for the most effective management of dry eye
This definition helps ophthalmologists and researchers to gain a comprehensive understanding of dryEye based on the international common understanding of the disease, and is well adopted to the cases of dry eye that are generally encountered in the clinical setting and animal models.
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This mini review provides a brief outline of key findings in the field of ocular ageing, draws comparisons with other mucosal tissues and discusses age-related changes in the context of immunopathogenesis of infectious keratitis and dry eye disease, two of the most common inflammatory disorders of the ocular surface.
Risk factors, incidence and persistence of symptoms from the eyes among professional computer users.
The incidence of eye-symptoms among professional computer users is high and related to both individual and work-related factors and the organization of computer work should secure frequent breaks from near-work at the computer screen.


A review of the Schirmer test for tear production.
Blotting paper is used to collect tears elicited by one of the following 3 methods of stimulating lacrimation: inserting the strip of paper itself; irritating the nasal mucosa after the cornea had been anesthetized, and having the patient look into the sun.
Tear Film Changes Associated with Normal Aging
There is a decline in tear film function throughout life and that tear flow is considerably less than previously estimated, and there was a decline associated with advancing age for all parameters except the decay constant and lipid volume.
Age-Related Modifications of Corneal Sensitivity
The age-related decrement of CS involves at first the corneal periphery and successively spreads toward the central zone, and both central and peripheral sensitivity decreased with age, and variations are represented by parabolic curves.
The effects of age, gender, and fluid dynamics on the concentration of tear film epidermal growth factor.
EGF concentrations is tear samples from normal humans were found to correlate with gender and Schirmer I value but not with tear clearance, and the Tear Function Index (TFI) was calculated.
Tear function index. A new measure of dry eye.
The tear function index offers a new method to evaluate tear production with the Schirmer test, introduces an extended way to measure tear flow combining with tear drainage, and gives a practical measure to diagnose dry eye.
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Although the etiologies of dry eye are varied, common to all ocular-surface disease is an underlying cytokine/receptor-mediated inflammatory process, by treating this process, it may be possible to normalize the ocular surface/lacrimal neural reflex and facilitate ocularsurface healing.
Relationship between tear volume and tear meniscus curvature.
This study confirmed that the volume of instilled eyedrops is linearly related to the resulting radius of the tear meniscus, suggesting that this radius is a useful measure in monitoring the tear volume.
Effect of environmental conditions on tear dynamics in soft contact lens wearers.
As AT and RH decreased, the tear film on the SCL became thinner, NIBUT became shorter, and dryness increased, which was more pronounced in eyes with SCL of the higher water content.