Using subsite coupling to predict signal peptides.

  title={Using subsite coupling to predict signal peptides.},
  author={K. C. Chou},
  journal={Protein engineering},
  volume={14 2},
Given a nascent protein sequence, how can one predict its signal peptide or "Zipcode" sequence? This is a first important problem for scientists to use signal peptides as a vehicle to find new drugs or to reprogram cells for gene therapy. Based on a model that takes into account the coupling effect among some key subsites, the so-called [-3, -1, +1] coupling model, a new prediction algorithm is developed. The overall rate of correct prediction for 1939 secretory proteins and 1440 non-secretary… CONTINUE READING
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Proteins : Struct

K. C. Chou, D. W. Elrod

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