Using state machines to model the Ion Torrent sequencing process and to improve read error rates

Abstract

MOTIVATION The importance of fast and affordable DNA sequencing methods for current day life sciences, medicine and biotechnology is hard to overstate. A major player is Ion Torrent, a pyrosequencing-like technology which produces flowgrams--sequences of incorporation values--which are converted into nucleotide sequences by a base-calling algorithm. Because… (More)
DOI: 10.1093/bioinformatics/btt212

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