Using splines to detect changes in PSA doubling times.

  title={Using splines to detect changes in PSA doubling times.},
  author={Brad W Guess and Robert I. Jennrich and Henry J Johnson and Ray Redheffer and Mark H Scholz},
  journal={The Prostate},
  volume={54 2},
BACKGROUND PSA doubling time (PSADT) can predict the likelihood of clinical progression in patients with biochemical relapse after surgery or radiation for prostate cancer. Changes in PSA doubling time in response to therapy may be of clinical or investigational significance. How does one estimate PSADT before and after the initiation of therapy and determine if any change is statistically significant or simply the result of random variation? These are the type of questions addressed. METHODS… CONTINUE READING

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