Using short-term response information to facilitate adaptive randomization for survival clinical trials.

@article{Huang2009UsingSR,
  title={Using short-term response information to facilitate adaptive randomization for survival clinical trials.},
  author={Xuelin Huang and Jing Ning and Yisheng Li and Elihu E Estey and Jean-Pierre Issa and Donald A. Berry},
  journal={Statistics in medicine},
  year={2009},
  volume={28 12},
  pages={1680-9}
}
Increased survival is a common goal of cancer clinical trials. Owing to the long periods of observation and follow-up to assess patient survival outcome, it is difficult to use outcome-adaptive randomization in these trials. In practice, often information about a short-term response is quickly available during or shortly after treatment, and this short-term response is a good predictor for long-term survival. For example, complete remission of leukemia can be achieved and measured after a few… CONTINUE READING