Using quantification of the PML-RARalpha transcript to stratify the risk of relapse in patients with acute promyelocytic leukemia.

@article{Santamara2007UsingQO,
  title={Using quantification of the PML-RARalpha transcript to stratify the risk of relapse in patients with acute promyelocytic leukemia.},
  author={Carlos M Santamar{\'i}a and Mar{\'i}a del Carmen Chill{\'o}n and C. Palomar Fern{\'a}ndez and Patricia Mart{\'i}n-Jim{\'e}nez and Ana Balanzategui and Ram{\'o}n Garc{\'i}a Sanz and Jes{\'u}s Fernando San Miguel and M G Gonz{\'a}lez},
  journal={Haematologica},
  year={2007},
  volume={92 3},
  pages={315-22}
}
BACKGROUND AND OBJECTIVES The detection of PML-RARalpha by real-time polymerase chain reaction (RQ-PCR) is becoming an important tool for monitoring minimal residual disease (MRD) in patients with acute promyelocytic leukemia (APL). However, its clinical value remains to be determined. Our aim was to analyze any associations between the risk of relapse and RQ-PCR results in different phases of treatment, comparing these data with those yielded by conventional qualitative reverse transcriptase… CONTINUE READING
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