Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease.

@article{Fleisher2011UsingPE,
  title={Using positron emission tomography and florbetapir F18 to image cortical amyloid in patients with mild cognitive impairment or dementia due to Alzheimer disease.},
  author={A Steven Fleisher and Kewei Chen and Xiaofen Liu and Auttawut Roontiva and Pradeep Thiyyagura and Napatkamon Ayutyanont and Abhinay D. Joshi and C. M. Clark and Mark A. Mintun and Michael J. Pontecorvo and P. Murali Doraiswamy and Keith A. Johnson and Daniel M. Skovronsky and Eric M. Reiman},
  journal={Archives of neurology},
  year={2011},
  volume={68 11},
  pages={1404-11}
}
OBJECTIVES To characterize quantitative florbetapir F 18 (hereafter referred to as simply florbetapir) positron emission tomographic (PET) measurements of fibrillar β-amyloid (Aβ) burden in a large clinical cohort of participants with probable Alzheimer disease (AD) or mild cognitive impairment (MCI) and older healthy controls (OHCs). DESIGN Cerebral-to-whole-cerebellar florbetapir standard uptake value ratios (SUVRs) were computed. Mean cortical SUVRs were compared. A threshold of SUVRs… CONTINUE READING
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