• Materials Science, Medicine
  • Published in
    International journal of…
    2013
  • DOI:10.2147/IJN.S45184

Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo

@inproceedings{Qiao2013UsingPA,
  title={Using poly(lactic-co-glycolic acid) microspheres to encapsulate plasmid of bone morphogenetic protein 2/polyethylenimine nanoparticles to promote bone formation in vitro and in vivo},
  author={Chunyan Qiao and Kai Zhang and Han Jin and Leiying Miao and Ce Shi and Xia Liu and Anliang Yuan and Jinzhong Liu and Daowei Li and Changyu Zheng and Guirong Zhang and Xiangwei Li and Bai Yang and Hongchen Sun},
  booktitle={International journal of nanomedicine},
  year={2013}
}
Repair of large bone defects is a major challenge, requiring sustained stimulation to continually promote bone formation locally. Bone morphogenetic protein 2 (BMP-2) plays an important role in bone development. In an attempt to overcome this difficulty of bone repair, we created a delivery system to slowly release human BMP-2 cDNA plasmid locally, efficiently transfecting local target cells and secreting functional human BMP-2 protein. For transfection, we used polyethylenimine (PEI) to create… CONTINUE READING

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