Using photo-initiated polymerization reactions to detect molecular recognition.

@article{Kaastrup2016UsingPP,
  title={Using photo-initiated polymerization reactions to detect molecular recognition.},
  author={Kaja Kaastrup and Hadley D. Sikes},
  journal={Chemical Society reviews},
  year={2016},
  volume={45 3},
  pages={
          532-45
        }
}
Widely used medical diagnostic devices and assays that sense the presence of a particular molecule in a bodily fluid often rely on either a nanoparticle label or an enzymatic reaction to generate a signal that is easily detectable. In many cases, it is desirable if the magnitude of the signal correlates with the concentration of the molecule of interest. Photo-initiated polymerization reactions are an alternative means of generating amplified signals that can be used to quantify biological… 
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References

SHOWING 1-10 OF 49 REFERENCES
Polymerization amplified detection for nanoparticle-based biosensing.
TLDR
A new assay platform is described that takes advantage of both polymerization reactions and the aggregation of nanoparticles to amplify signal, in which radicals generated by either enzymes or metal ions are polymerized to form polymers that can entangle multiple gold nanoparticles into aggregates, resulting in a visible color change.
Using polymeric materials to generate an amplified response to molecular recognition events.
TLDR
This work investigates harnessing the amplification inherent in a radical chain polymerization reaction to detect molecular recognition, and shows a macroscopically observable polymer, easily visible to the unaided eye, as a result of as few as approximately 1,000 recognition events.
Balancing the initiation and molecular recognition capabilities of eosin macroinitiators of polymerization-based signal amplification reactions.
TLDR
The present work addresses the question of how detection sensitivity is impacted when the number of eosin molecules per binding event increases in the range of two to fifteen and a non-monotonic relationship is observed between theNumber of initiators per bindingevent and the observed detection sensitivity.
Investigation of dendrimers functionalized with eosin as macrophotoinitiators for polymerization-based signal amplification reactions
TLDR
It is shown that quenching effects impact the efficacy of these conjugates as macrophotoinitiators, and a poly(amidoamine) dendrimer is used as a scaffold to produce conjugate with enhanced solubility.
Signal amplification strategies for DNA and protein detection based on polymeric nanocomposites and polymerization: A review.
Impact of dissociation constant on the detection sensitivity of polymerization-based signal amplification reactions.
TLDR
This work provides the first systematic study of how the dissociation constant impacts detection sensitivity in polymerization-based amplification assays, having chosen a range of dissociation constants that is typical of those encountered in molecular diagnostic applications that detect protein-protein binding events.
Polymerization-based signal amplification under ambient conditions with thirty-five second reaction times.
TLDR
This system achieves sensitivities comparable to those reported for inert gas-purged systems and requires significantly shorter reaction times than other implementations of polymerization-based amplification.
Development of fluorescent polymerization-based signal amplification for sensitive and non-enzymatic biodetection in antibody microarrays.
Electrochemical biosensing using amplification-by-polymerization.
TLDR
The results show that the coupling of amplification-by-polymerization concept with electrochemical detection offers great promises in providing a sensitive and cost-effective solution for biosensing applications.
Photopolymerization as a promising method to sense biorecognition events
...
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